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TriLink BioTechnologies Nucleotides
It is likely that among TriLink’s wide selection of modified nucleoside triphosphates (NTPs) you will find a compound to suit your application. We stock over 150 modified compounds, including Aminoallyl, Biotin and 2' Fluoro nucleotides. In addition, we offer specialty modified nucleotides such as bisphosphates, a series of monophosphates and CAP and mCAP. Whether your studies involve indirect DNA labeling, cDNA synthesis, nuclease resistance or a new application, we have the right modified NTP. Additionally, our nucleic acid chemists are experts in the synthesis of unique NTPs. Please inquire for larger quantities or specific concentrations.
TriLink BioTechnologies Custom Chemistry
Our custom chemistry and contract research services include synthesis of unique phosphoramidites and polyphosphates, including mono-, di- and triphosphates, and other small molecules. If the small molecule your research requires is not commercially available, contact us. Collectively, our R&D team has decades of experience developing and optimizing nucleic acid synthesis schemes.
A New Approach to Early Phase Therapeutic GMP Manufacturing
For over 20 years, we’ve been industry leaders synthesizing high quality research and diagnostic grade material, especially difficult and unusual constructs. Now we’re combining our expertise with a new state-of-the art GMP manufacturing facility to expand our services into mRNA and oligonucleotide therapeutics.
Our new, 2,000 square foot GMP facility is dedicated to manufacturing therapeutic products and is ISO certified by Lloyd’s Register. The controlled labs feature:
Manufacturing of therapeutic grade material is available for:
To begin discussions and obtain a quote for your project, please send us a request. We’ll start with an intake meeting, where we’ll discuss your project, expectations and timelines. From there, we’ll work with you to determine the most effective and efficient process for your particular project. Although we may customize each project to meet your specific needs, the basic steps are outlined below.
Affordable Custom Synthesis
Genome Editing & Manipulation Tools
Zinc-finger nucleases, TALENS, CRISPR and recombinases
Gene Replacement, Immunotherapy & Delivery Optimization
mRNA for non-integrating generation of iPSCs
Please contact us to discuss your path to pharmaceutical GMP manufacturing.
CleanAmp™ Hot Start PCRCleanAmp™ Hot Start PCR is a patented technology developed under SBIR grants from the NIH. CleanAmp™ Hot Start PCR products provide a specific, sensitive and flexible alternative to Hot Start DNA polymerases. TriLink has applied their expertise in modified nucleic acid chemistry to develop chemically modified dNTPs and primers that enable Hot Start PCR using standard Taq DNA polymerase. Simply swap out the standard dNTPs or primers in your PCR assay for the corresponding CleanAmp™ product to create a Hot Start PCR reaction. CleanAmp™ products are ideal for applications such as RT-PCR, multiplex PCR, digital PCR, fast PCR, end-point PCR and real-time PCR (including real-time RT-PCR and fast real-time PCR). CleanAmp™ Hot Start PCR products offer:
• Compatibility with all DNA polymerases and PCR applications
• Unparalleled specificity and sensitivity due to significantly reduced non-specific amplification
• Easy assay development with minimal optimization
• Increased product yield
• High amplification efficiency with short and long amplicons (up to 23kb)
• Significant cost savings over other Hot Start technologies, including affordable licensing opportunities
CleanAmp™ dNTP Mix eliminates primer dimer formation.
CleanAmp™ Primers improve PCR performance in systems prone to (A) primer dimer formation and (B) mis-priming.
Activation of CleanAmp™ Products occurs during the initial heat cycle of Hot Start PCR and each subsequent denaturation step, releasing just enough reagent to allow efficient amplification. By limiting the amount of active reagent during the early cycles when the target is in low concentration, CleanAmp™ significantly reduces background amplification to achieve a reduction or even an elimination of primer dimer and mis-priming.